ISEIRE :: Publications

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There are currently 15 publications available from ISEIRE.

	VO2 peak vs. VO2 max Professor B Whipp Exclusive to ISEIRE The term VO2 max has almost become common English usage for the highest VO2 obtained during a CPET. This article clearly explains the difference between VO2 max and VO2 peak.
	Some facts and some thoughts on the history of oxygen uptake and its measurement Dr Paul Older Exclusive to ISEIRE This paper is a brief history of our knowledge of oxygen uptake. It starts just before Lavoisier and ends in our time. The file is 1 MB (there are five pictures) so it may take a while to load.
	When is 863 actually 863? Brian J. Whipp, Ph.D., D.Sc. Institute of Membrane and Systems Biology, Leeds In order to adequately understand the behavior of a physiological system it is important to characterize both its control and regulatory features. By control is meant the change in the magnitude of a particular variable, in response to a physiological stressor, that operates to establish the relative stability of another (i.e. the regulated variable) to some degree of adequacy. A typical example would be the change in alveolar ventilation (Va) , the controlled variable), or its functional counterpart the minute ventilation (Ve) which stabilizes the level of arterial PCO2 (PaCO2, the regulated variable) at, or close to, its set point value in response to the increased pulmonary CO2 output (VCO2 ) demands of muscular exercise of moderate intensity
	Recommendations on the clinical use of exercise testing in clinical practice P Palange, SA Ward, K-H Carlsen et al Eur Respir J 2007: 29; 185-209 This is an excellent review article which is available in full on www.erj.ersjournals.com/cgi/content/full/29/1/185
	Alveolar-arterial gas tension differences during graded exercises Whipp BJ & Wasserman K Journal of Applied Physiology Vol.27, No 3, September 1969 This paper measures both arterial and gas exchange data and publishes the A-a gradient for oxygen and the a-A gradient for carbon dioxide. The paper also provides measurements for Vd/Vt, Qva/Qt. Although it was published in 1969 it remains as pertinent today as it was then.
	Aerobically generated CO2 stored during early exercise Chuang, M. L. Ting, H. Otsuka, T. et al J Appl Physiol 87:1087-1097; 1999 This paper discusses the acid base changes that occur in the first 90 secs of exercise. It goes into the initial alkalosis of exercise.
	Diagnosing Cardiovascular and Lung Pathophysiology From Exercise Gas Exchange Karlman Wasserman, MD, PhD, FCCP Chest 1997; 112: 1091-1101 A classic paper describing diagnosis of cardio-pulmonary pathophysiology from CPET.
	Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients Paolo Palange, Gabriele Valli, Paolo Onorati, Rosa Antonucci, Patrizia Paoletti, Alessia Rosato, Felice Manfredi, and Pietro Serra J Appl Physiol 97: 1637–1642, 2004. This paper looks at the effect of Heliox on lung mechanics and exercise capacity using CPET.
	A Treadmill Ramp Protocol Using Simultaneous Changes in Speed and Grade Janos Porszasz, Richard Casaburi, Attila Somfay, Linda J. Woodhouse, and Brian J. Whipp Med. Sci. Sports Exerc., Vol. 35, No. 9, pp. 1596-1602, 2003 This paper provides a treadmill protocol to provide a linear work rate profile.
	Effects of Whole-Body Exercise Training on Body Composition and Functional Capacity in Normal-Weight Patients With COPD Frits M.E. Franssen, Roelinka Broekhuizen, Paul P. Janssen, Emiel F.M. Wouters, Annemie M.W. Schols Chest 2004; 125:2021-2028 This article looks at the effects of exercise training on body composition and functional capacity in normal weight patients with COPD
	Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing Romualdo Belardinelli, Francesca Lacalaprice, Flavia Carle, Adelaide Minnucci, Giovanni Cianci, GianPiero Perna, Giuseppe D'Eusanio European Heart Journal (2003) 24, 1304-1313 This paper looks at using CPET to improve accuracy of standard ECG stress testing in identifying exercise induced myocardial ischaemia.
	Work-rate affects cardiopulmonary exercise test results in heart failure Piergiuseppe Agostonia, Michele Bianchia, Andrea Moraschia, Pietro Palermoa, Gaia Cattadoria, Rocco La Gioiab, Maurizio Bussottia, Karlman Wasserman Europ J of Heart Failure 2005; 7: 498-504 This paper examines the effect that exercise protocol may have on CPET measurements.
	Pulmonary O2 Uptake during Exercise: Conflating Muscular and Cardiovascular Responses Brian J. Whipp, Susan A. Ward, and Harry B. Rossiter Med. Sci. Sports Exerc., Vol. 37, No. 9, pp. 1574-1585, 2005 The ability to develop high levels of aerobic energy transfer is important in most athletic activities and many everyday activities. This paper describes the possible mechanisms.
	Gas Exchange Responses to Constant Work-Rate Exercise in Patients with Glycogenosis Type V and VII Hean-Yee Ong, Conor S. O’Dochartaigh, Sharon Lovell, Victor H. Patterson, Karlman Wasserman, D. Paul Nicholls, and Marshall S. Riley Am J Respir Crit Care Med, Vol 169. pp 1238-1244, 2004 This paper looks at CPET responses to constant work rate exercise. It utilises patients with McArdles disease.
	Cardiopulmonary Exercise Testing as a Screening Test for Perioperative Management of Major Surgery in the Elderly Paul Older, MBBS; Adrian Hall, MBBS; and Raymond Hader, MBBS Chest 1999; 116: 355-362 This paper looks at the use of CPET for evaluation of perioperative risk.